Multimodal biophysical markers of neurodegeneration: Morphology, mechanics, and thermodynamics.
Multimodal biophysical markers of neurodegeneration: Morphology, mechanics, and thermodynamics.
Where did the research take place?
The study site has not been established. Author addresses may differ from where the research occurred.
Sofia, BG · Author affiliation
Institute of Biophysics and Biomedical Engineering, Bulgarian Academy of Sciences, "Acad. G. Bonchev" Str. 21, 1113 Sofia, Bulgaria; Faculty Life Sciences, Reutlingen University, Alteburgstraße 150, 72762 Reutlingen, Germany.Location evidence
Reutlingen, DE · Author affiliation
Institute of Biophysics and Biomedical Engineering, Bulgarian Academy of Sciences, "Acad. G. Bonchev" Str. 21, 1113 Sofia, Bulgaria; Faculty Life Sciences, Reutlingen University, Alteburgstraße 150, 72762 Reutlingen, Germany.Location evidence
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Original abstract
The identification of novel noninvasive biomarkers remains a major challenge in the diagnosis of neurodegenerative diseases. Significant efforts focus on fluid biomarkers, including proteins, peptides, and miRNAs, detectable in blood plasma and peripheral blood cells. Here, we review recent findings on blood plasma and peripheral blood cells physical parameters in Alzheimer's disease, Parkinson's disease and amyotrophic lateral sclerosis emphasizing atomic force microscopy and calorimetry assay. Alterations in morphology, nanostructure, and stiffness of red blood cells and platelets, together with thermodynamic signatures of red blood cells and plasma, provide sensitive indicators of disease-related changes. These integrated biophysical parameters not only distinguish neurodegeneration from healthy states but also enable discrimination among different neurodegenerative disorders, highlighting their potential as minimally invasive diagnostic markers.