The Multiple Sclerosis Severity Allele rs10191329A and Cognitive Function: A UK Biobank Study.
The Multiple Sclerosis Severity Allele rs10191329A and Cognitive Function: A UK Biobank Study.
Where did the research take place?
The study site has not been established. Author addresses may differ from where the research occurred.
London, GB · Author affiliation
Centre for Preventive Neurology, Wolfson Institute of Population Health, Queen Mary University of London, UK.Location evidence
Montréal, CA · Author affiliation
The Neuro (Montreal Neurological Institute-Hospital), Montréal, Québec, Canada.Location evidence
Québec, CA · Author affiliation
The Neuro (Montreal Neurological Institute-Hospital), Montréal, Québec, Canada.Location evidence
SE · Author affiliation · country only
Department of Clinical Neuroscience, Karolinska Institute, Sweden.Location evidence
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Original abstract
The genome-wide association study of Multiple Sclerosis severity linked the genetic variant rs10191329A to long-term disability and implicated brain resilience as a determinant of outcome. We hypothesised that rs10191329A might influence cognition in other neurological diseases and healthy controls. We explored the relationship between rs10191329A and cognition using reaction time, fluid intelligence, and prospective memory tests in the UK Biobank. We observed weak but directionally consistent associations between rs10191329A and poorer cognition in controls, with similar but non-significant trends in Multiple Sclerosis, Parkinson's disease, and dementia. Our results support the hypothesis that rs10191329A might affect multiple sclerosis outcomes by affecting brain health.