3D-printed lab-on-chip platforms for the detection of neurodegenerative diseases: opportunities and challenges.
3D-printed lab-on-chip platforms for the detection of neurodegenerative diseases: opportunities and challenges.
Where did the research take place?
The study site has not been established. Author addresses may differ from where the research occurred.
Daegu, KR · Author affiliation
Department of Robotics and Mechatronics Engineering, Daegu Gyeongbuk Institute of Science and Technology (DGIST), Dalseong-gun, Daegu, 42988, South Korea. sspritamrath93@gmail.com.Location evidence
Vadodara, IN · Author affiliation
Department of Computer Engineering, Parul Institute of Engineering and Technology (PIET), Parul University, Ta. Waghodia, Vadodara, Gujarat 391760, India. richa.mishra31240@paruluniversity.ac.in.Location evidence
IN · Author affiliation · country only
Uttaranchal Institute of Technology, Uttaranchal University, Dehradun-248007, India.Location evidence
Ranchi, IN · Author affiliation
Amity Institute of Biotechnology, Amity University Jharkhand, Ranchi 834002, India. smalik@rnc.amity.edu.Location evidence
Dehradun, IN · Author affiliation
Department of Food Technology, Dev Bhoomi Uttarakhand University, Dehradun, Uttarakhand, India.Location evidence
Coimbatore, IN · Author affiliation
Centre for Natural Products and Functional Foods, Karpagam Academy of Higher Education, Coimbatore, Tamil Nadu, 641021, India. biogovindarajan@gmail.com.Location evidence
Noida, IN · Author affiliation
Department of Life Sciences, School of Biosciences and Technology, Sharda University, Noida 201301, UP, India. sounip@gmail.com.Location evidence
Rajpura, IN · Author affiliation
Centre for Research Impact and Outcome, Chitkara University, Rajpura 140417, Punjab, India.Location evidence
Guwahati, IN · Author affiliation
Program of Biotechnology, Faculty of Science, Assam Down Town University, Guwahati 781026, Assam, India. Nayanpakhi@gmail.com.Location evidence
KR · Author affiliation · country only
Department of Biotechnology, Yeungnam University, Gyeongsan 38541, Gyeongbuk, Republic of Korea. rabbi.biotech@gmail.com.Location evidence
Chandigarh, IN · Author affiliation
University Center for Research & Development (UCRD) Chandigarh University, NH-05 Chandigarh- Ludhiana Highway, Mohali, Punjab, India.Location evidence
Ludhiana, IN · Author affiliation
University Center for Research & Development (UCRD) Chandigarh University, NH-05 Chandigarh- Ludhiana Highway, Mohali, Punjab, India.Location evidence
Mohali, IN · Author affiliation
University Center for Research & Development (UCRD) Chandigarh University, NH-05 Chandigarh- Ludhiana Highway, Mohali, Punjab, India.Location evidence
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Original abstract
Neurodegenerative diseases (NDs) such as Alzheimer's, Parkinson's, and ALS remain some of the most challenging disorders to diagnose at an early stage. Conventional approaches rely on costly neuroimaging or invasive cerebrospinal fluid sampling, which limit accessibility and early intervention. Recent advances in 3D printing have enabled rapid prototyping of lab-on-chip (LOC) platforms that integrate microfluidics, biosensors, and biological models to detect disease-specific biomarkers with high sensitivity and throughput. Herein, we explore the synergistic role of 3D printing technologies and biomaterials in fabricating LOC systems for NDs. We highlight key biomarkers, and neuron- and organoid-on-chip platforms, and discuss the challenges and opportunities in clinical translation. By combining technical innovation in additive manufacturing with biological relevance, 3D-printed LOC devices represent a transformative approach toward precision diagnostics in neuro-medicine.