Generation of an induced pluripotent stem cell line (NIMHi28-A) from a parkinsonian-type multiple system atrophy patient of Indian origin.
Generation of an induced pluripotent stem cell line (NIMHi28-A) from a parkinsonian-type multiple system atrophy patient of Indian origin.
Where did the research take place?
The study site has not been established. Author addresses may differ from where the research occurred.
Bengaluru, IN · Author affiliation
Department of Biophysics, National Institute of Mental Health and Neurosciences, Bengaluru 560029, Karnataka, India.Location evidence
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Original abstract
Multiple System Atrophy (MSA) is a rare, adult-onset, and rapidly progressive neurodegenerative disorder characterized by motor dysfunction and autonomic failure, with an estimated prevalence of 1.9-4.9 per 100,000 individuals per year. Clinically, MSA is broadly classified into two major phenotypes: cerebellar-dominant (MSA-C) and Parkinsonian-dominant (MSA-P). In this study, induced pluripotent stem cells (iPSCs) were generated from peripheral blood mononuclear cells of a clinically diagnosed MSA-P patient using Sendai virus-mediated reprogramming. Detailed characterization demonstrated robust self-renewal capacity and expression of key markers associated with the undifferentiated pluripotent state. This iPSC line represents a valuable biological resource for modelling disease mechanisms in patient-derived cell types and provides a promising platform for biomarker identification and therapeutic drug screening.