Current advances in PDGF isoform specificity and variable functions in aging-associated neurological disorders.
Current advances in PDGF isoform specificity and variable functions in aging-associated neurological disorders.
Where did the research take place?
The study site has not been established. Author addresses may differ from where the research occurred.
Wuhan, CN · Author affiliation
Department of Anesthesiology and Pain Medicine, Hubei Key Laboratory of Geriatric Anesthesia and Perioperative Brain Health, and Wuhan Clinical Research Center for Geriatric Anesthesia, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.Location evidence
Xiangyang, CN · Author affiliation
Hubei Provincial Clinical Research Center for Parkinson's Disease, Central Laboratory, Xiangyang No. 1 People's Hospital, Hubei University of Medicine, Xiangyang 44100, China.Location evidence
Jiangxi, CN · Author affiliation
Department of Anesthesiology, Jiangxi Maternal and Child Health Hospital, Nanchang Medical College, Nanchang 330000, China.Location evidence
Nanchang, CN · Author affiliation
Department of Anesthesiology, Jiangxi Maternal and Child Health Hospital, Nanchang Medical College, Nanchang 330000, China.Location evidence
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Original abstract
Among the signaling molecules that influence the health and pathology of central nervous system (CNS), Platelet-derived growth factor (PDGF) has emerged as a pivotal regulator of neurogenesis, neuroinflammation, and neuronal survival. However, the isoform-specific signaling of PDGF in aging-related neurological disorders remains under-characterized, and the interplay between PDGF and cellular senescence in CNS is inadequately understood. Additionally, the dual role of PDGFs signaling remains underexplored, especially in aging-related neurological disorders. This review aims to address these gaps by analyzing the roles of five PDGF isoforms in CNS functions, PDGFs downstream signaling in the nervous system, PDGF's modulation of neural components, and its role in aging-related diseases including Stroke, Alzheimer's Disease (AD), Parkinson's Disease (PD), and Glioblastoma (GBM). In this review, we highlight the effects of PDGF isoforms in the CNS vary with experimental conditions, dosage, cellular microenvironment and aging status. This review provides a comparative analysis of PDGF isoform-specific functions, emphasizing age-dependent signaling shifts and potential therapeutic implications.