QSM vs dopamine transporter PET: χ+ Mapping Shows Stronger Longitudinal Associations with Nigral Degeneration than Conventional QSM in Parkinson's Disease.
QSM vs dopamine transporter PET: χ+ Mapping Shows Stronger Longitudinal Associations with Nigral Degeneration than Conventional QSM in Parkinson's Disease.
Where did the research take place?
The study site has not been established. Author addresses may differ from where the research occurred.
Xuzhou, CN · Author affiliation
From the Department of Radiology (C.Z., M.S., Q.Z., C.S., A.G.R., P.S., Y.W.),Weill Cornell Medicine, Cornell University, NewYork, NewYork, USA; Department of Radiology (C. Z., C.H.), Affiliated hospital of Xuzhou Medical University, Xuzhou, Jiangsu, P.R. China; Department of Electrical and Computer Engineering (M.S., A.G.R.), Cornell University, Ithaca, New York, USA; Department of Neurology (A.S.), Weill Cornell Medicine, New York-Presbyterian Hospital, New York, New York, USA and Department of Neurology (A.S.), Hospital for Special Surgery, NewYork, NewYork, USA.Location evidence
Ithaca, US · Author affiliation
From the Department of Radiology (C.Z., M.S., Q.Z., C.S., A.G.R., P.S., Y.W.),Weill Cornell Medicine, Cornell University, NewYork, NewYork, USA; Department of Radiology (C. Z., C.H.), Affiliated hospital of Xuzhou Medical University, Xuzhou, Jiangsu, P.R. China; Department of Electrical and Computer Engineering (M.S., A.G.R.), Cornell University, Ithaca, New York, USA; Department of Neurology (A.S.), Weill Cornell Medicine, New York-Presbyterian Hospital, New York, New York, USA and Department of Neurology (A.S.), Hospital for Special Surgery, NewYork, NewYork, USA.Location evidence
New York City, US · Author affiliation
From the Department of Radiology (C.Z., M.S., Q.Z., C.S., A.G.R., P.S., Y.W.),Weill Cornell Medicine, Cornell University, NewYork, NewYork, USA; Department of Radiology (C. Z., C.H.), Affiliated hospital of Xuzhou Medical University, Xuzhou, Jiangsu, P.R. China; Department of Electrical and Computer Engineering (M.S., A.G.R.), Cornell University, Ithaca, New York, USA; Department of Neurology (A.S.), Weill Cornell Medicine, New York-Presbyterian Hospital, New York, New York, USA and Department of Neurology (A.S.), Hospital for Special Surgery, NewYork, NewYork, USA.Location evidence
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Original abstract
BACKGROUND: Iron accumulation in the substantia nigra (SN) is a hallmark of Parkinson's disease (PD). Quantitative susceptibility mapping (QSM) including source separation can generate maps of total susceptibility χ, paramagnetic or positive susceptibility [Formula: see text] likely dominated by tissue iron, and diamagnetic or negative susceptibility [Formula: see text] reflecting myelin and other sources. PURPOSE: To compare χ, [Formula: see text], and [Formula: see text] for tracking SN longitudinal changes in PD and for correlating with dopaminergic PET measures and cognitive decline. MATERIALS AND METHODS: This longitudinal study included 32 patients with PD (mean age, 65.88 ± 8.47 years) who underwent 3T MRI with 3D multi-echo gradient-echo (mGRE) and dynamic 11C-N-(3-iodoprop-2E-enyl)-2β-carbomethoxy-3β-(4-methylphenyl) nortropane (PE2I) PET between August 2018 and April 2024. χ, [Formula: see text], and [Formula: see text] maps were reconstructed from mGRE data using the MEDI algorithm with susceptibility source separation. Dopamine transporter binding potential (BP) images were estimated from dynamic PET using a deep learning based kinetic model. Paired t tests, linear regression, and Pearson correlation analyses with Bonferroni correction were performed, with P < .05 considered significant. RESULTS: Both χ and [Formula: see text] from QSM revealed significant longitudinal susceptibility increases in the rostral and caudal SN (Bonferroni-corrected P < .05), with [Formula: see text] showing larger effect sizes (t = 9.99 vs 2.65 for the caudal SN). The left putaminal BP from PET significantly decreased at follow-up (P < .05). The longitudinal increase in [Formula: see text] within the rostral SN strongly correlated with the reduction in putaminal BP (r = - 0.60, P = .005, Bonferroni-corrected), whereas χ showed no significant association. Higher baseline [Formula: see text] values in the rostral and caudal SN predicted greater longitudinal cognitive decline (P = .01-.02, Bonferroni-corrected). Subregional analyses confirmed significant [Formula: see text] increases predominantly in the rostral-anterior SN. No significant change or correlation was observed with [Formula: see text] mapping at the SN. CONCLUSION: Positive susceptibility [Formula: see text] mapping showed larger longitudinal effect sizes for SN changes and stronger associations with dopaminergic PET decline and cognitive deterioration than to total susceptibility χ. These findings support [Formula: see text] mapping as a biologically informative MRI measure for the longitudinal assessment of SN changes in PD.