Deubiquitinases at organelle quality control bottlenecks in neurodegeneration.
Deubiquitinases at organelle quality control bottlenecks in neurodegeneration.
Where did the research take place?
The study site has not been established. Author addresses may differ from where the research occurred.
Novato, US · Author affiliation
Buck Institute for Research on Aging, Novato, CA 94945, USA. Electronic address: lellerby@buckinstitute.org.Location evidence
Tel Aviv, IL · Author affiliation
Department of Cellular, Developmental, and Regenerative Biology, Gray School of Medical Sciences, Gray Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv 6997801, Israel; Sagol School of Neuroscience, Tel Aviv University, Tel Aviv 6997801, Israel. Electronic address: ashkenaziavi@tauex.tau.ac.il.Location evidence
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Original abstract
Neurodegenerative diseases with prominent motor symptoms converge on mitochondrial and lysosomal bottlenecks in selectively vulnerable neurons. Deubiquitinases regulate ubiquitin-dependent organelle fate at these decision points. Emerging evidence suggests that modulating deubiquitinase activity can restore organelle quality control and represents a promising therapeutic strategy.