Parkinson's disease-subjective cognitive decline and health-related quality of life.
Parkinson's disease-subjective cognitive decline and health-related quality of life.
Where did the research take place?
The study site has not been established. Author addresses may differ from where the research occurred.
Barcelona, ES · Author affiliation
Medicine Department, Universitat Autònoma de Barcelona (UAB), Barcelona, Spain. jrodriguezmu@santpau.cat.Location evidence
Centro, ES · Author affiliation
Centro de Investigación Biomédica en Red-Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain. jrodriguezmu@santpau.cat.Location evidence
Madrid, ES · Author affiliation
Centro de Investigación Biomédica en Red-Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain. jrodriguezmu@santpau.cat.Location evidence
Vigo, ES · Author affiliation
Neurology Department, Hospital Álvaro Cunqueiro, Complejo Hospitalario Universitario de Vigo (CHUVI), Vigo, Spain.Location evidence
Lugo, ES · Author affiliation
Hospital Universitario Lucus Augusti (HULA), Lugo, Spain.Location evidence
Elche, ES · Author affiliation
Neurology Department, Hospital General Universitario de Elche, Elche, Spain.Location evidence
Sant Joan Despí, ES · Author affiliation
Neurology Department, Complex Hospitalari Universitari Moisés Broggi, Sant Joan Despí, Spain.Location evidence
Pontevedra, ES · Author affiliation
Neurology Department, Complejo Hospitalario Universitario de Pontevedra (CHOP), Pontevedra, Spain.Location evidence
Burgos, ES · Author affiliation
Neurology Department, Complejo Asistencial Universitario de Burgos, Burgos, Spain.Location evidence
Sevilla, ES · Author affiliation
Neurology Department, Hospital Universitario Virgen Macarena, Sevilla, Spain.Location evidence
Tortosa, ES · Author affiliation
Servei de Neurologia, Hospital Universitari de Tortosa Verge de la Cinta, Institut Català de la Salut, Tortosa, Spain.Location evidence
Palma, ES · Author affiliation
Neurology Department, Centro Neurológico Oms 42, Palma de Mallorca, Spain.Location evidence
Pamplona, ES · Author affiliation
Neurology Department, Complejo Hospitalario de Navarra, Pamplona, Spain.Location evidence
Móstoles, ES · Author affiliation
Hospital Universitario de Móstoles, Madrid, Spain.Location evidence
Santander, ES · Author affiliation
Neurology Department, Hospital Universitario Marqués de Valdecilla, Santander, Spain.Location evidence
Toledo, ES · Author affiliation
Neurology Department, Complejo Hospitalario de Toledo, Toledo, Spain.Location evidence
Oviedo, ES · Author affiliation
Neurology Department, Hospital Universitario Central de Asturias, Oviedo, Spain.Location evidence
Terrassa, ES · Author affiliation
Neurology Department, Hospital Universitari Mutua de Terrassa, Terrassa, Spain.Location evidence
Ferrol, ES · Author affiliation
Neurology Department, Complejo Hospitalario Universitario de Ferrol (CHUF), Ferrol, Spain.Location evidence
ES · Author affiliation · country only
Neurology Department, Hospital Universitario Donostia, Donostia, Spain.Location evidence
Girona, ES · Author affiliation
Neurology Department, Institut d'Assistència Sanitària (IAS)-Institut Català de la Salut, Girona, Spain.Location evidence
Valencia, ES · Author affiliation
Neurology Department, Hospital Arnau de Vilanova, Valencia, Spain.Location evidence
Alcorcón, ES · Author affiliation
Neurology Department, Hospital Fundación Alcorcón, Madrid, Spain.Location evidence
Universidad, ES · Author affiliation
Unidad de Trastornos del Movimiento, Servicio de Neurología, Instituto de Biomedicina de Sevilla, Hospital Universitario Virgen del Rocío, Universidad de Sevilla, Seville, Spain.Location evidence
A Coruña, ES · Author affiliation
Neurology Department, Complejo Hospitalario Universitario de A Coruña (CHUAC), INIBIC, A Coruña, Spain.Location evidence
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Original abstract
BackgroundParkinson's disease-subjective cognitive decline (PD-SCD) is defined by subjective cognitive complaints (SCC) in the absence of objective cognitive impairment and has been associated with an increased risk of future cognitive decline. However, its impact on health-related quality of life (HRQoL) remains unclear. This is particularly relevant in early PD, when patients often maintain high levels of social-occupational functioning and subtle cognitive concerns may interfere with daily life. This study aimed to explore the association between SCC and HRQoL in cognitively unimpaired PD patients (PD-SCD).MethodsCross-sectional data from the COPPADIS cohort were analyzed. Patients with normal cognition according to PD-MCI level I criteria (Parkinson's Disease-Cognitive Rating Scale > 81) were included. HRQoL was assessed using the 39-item Parkinson's Disease Questionnaire (PDQ-39). SCC were defined as a Non-Motor Symptoms Scale (NMSS) domain 5 ≥ 1.ResultsA total of 497 patients with median age 62 years, disease duration 4 years, and 61% of PD-SCD were included. HRQoL was significantly worse in PD-SCD patients across all PDQ-39 domains. In adjusted linear regression models, PD-SCD was independently associated with higher PDQ-39 total score as well as with worse scores in activities of daily living, social support, cognition, and communication domains.ConclusionsPD-SCD is independently associated with poorer HRQoL across multiple domains. These findings highlight the clinical relevance of SCC within a patient-centered approach to PD management.