Eating Disorders and Parkinson's Disease-1: Comorbidities, Neurobiology, and Family History.
Eating Disorders and Parkinson's Disease-1: Comorbidities, Neurobiology, and Family History.
Where did the research take place?
The study site has not been established. Author addresses may differ from where the research occurred.
San Diego, US · Author affiliation
University of California San Diego (UCSD), La Jolla, California, USA.Location evidence
La Jolla, US · Author affiliation
University of California San Diego (UCSD), La Jolla, California, USA.Location evidence
Oregon, US · Author affiliation
Oregon Research Institute (ORI), Springfield, Oregon, USA.Location evidence
US · Author affiliation · country only
Williwaw Biosciences LLC, Clarkston, Michigan, USA.Location evidence
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Original abstract
ObjectiveEating disorders (ED), particularly anorexia nervosa (AN), share neurobiological characteristics with Parkinson's Disease (PD) (e.g., premorbid anxiety, dopaminergic dysfunction, harm avoidance, weight loss), suggesting common vulnerability. The present study built upon these observations, an AN patient's reported family history of Parkinson's Disease (RFHoPD), and AN:PD genetic correlation estimates, by ascertaining RFHoPD in families of individuals with PD.MethodWe ascertained RFHoPD among ED patients and community participants, and estimated relative risks (RRs) for AN, Bulimia Nervosa (BN), and Binge Eating Disorder (BED).ResultsIn the total sample (N = 1135), we observed increased RFHoPD among patients and community participants meeting criteria for ED diagnoses (n = 727) versus community participants without an ED diagnosis (n = 408). For AN, RFHoPD prevalence was 6.6%, versus 3.4% (χ2 = 4.638, p = 0.031, RR = 1.935, 95% Confidence Interval [CI] = 1.012-3.768). For BN, RFHoPD prevalence was 7.4%, versus 3.4% (χ2 = 4.941, p = 0.026, RR = 2.169, 95% CI = 1.023-4.620). For BED, RFHoPD prevalence was 13.3%, versus 3.4% (χ2 = 6.953, p = 0.008, RR = 3.886, 95% CI = 1.108-11.524).ConclusionsED are associated with elevated RFHoPD. Analyses leveraging disorder-specific research may improve understanding of shared risk factors.