The effect of combined motor and cognitive rehabilitation on motor performance in Parkinson's disease: a systematic review and meta-analysis.
The effect of combined motor and cognitive rehabilitation on motor performance in Parkinson's disease: a systematic review and meta-analysis.
Where did the research take place?
Possible study sites were matched from the text; these need review.
Cochrane, CA · Possible study site
MethodsA search was conducted in PubMed, Embase, Scopus, Web of Science, and Cochrane Library.Location evidence
Venice, IT · Author affiliation
Healthcare Innovation Technology Lab, IRCCS San Camillo Hospital, Venice, Italy.Location evidence
Bologna, IT · Author affiliation
Translational Rehabilitation Sciences Group, Department of Biomedical and Neuromotor Sciences (DIBINEM), Alma Mater Studiorum University of Bologna, Bologna, Italy.Location evidence
Padua, IT · Author affiliation
School of Psychology, University of Padua, Padua, Italy.Location evidence
Luxembourg, LU · Author affiliation
Department of Health, LUNEX, Differdange, Luxembourg; Luxembourg Health & Sport Sciences Research Institute ASBL, Differdange, Luxembourg.Location evidence
Rzeszów, PL · Author affiliation
College of Medical Sciences, University of Rzeszow, Rzeszow, Poland.Location evidence
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Original abstract
ObjectiveTo evaluate the effectiveness of sequential and simultaneous motor and cognitive treatment on motor functions, activities of daily living, and quality of life in people with Parkinson's disease.DesignSystematic review and meta-analysis.Subjects/patientsPatients with Parkinson's disease.MethodsA search was conducted in PubMed, Embase, Scopus, Web of Science, and Cochrane Library. Functional mobility was assessed as the main outcome, and balance, gait, activities of daily living, and quality of life as secondary outcomes. Meta-analyses were conducted using mean difference or standardized mean difference with 95% confidence intervals and fixed or random effect models. Heterogeneity was explored, setting a cut-off value of I2 = 50%.ResultsSixteen studies were included, with 8 -eligible for meta-analysis. Results showed that sequential combined treatment offered no clear advantage over motor rehabilitation alone for functional mobility, although a significant benefit was found for activities of daily living. Results on simultaneous combined treatment suggested improvements in quality of life, but no significant differences between treatments for functional mobility.ConclusionMotor-cognitive approaches may enhance prefrontal cortex efficiency, supporting complex motor tasks and reducing the risk of falls. Future research should elucidate neural mechanisms and compare simultaneous and sequential strategies to develop personalized, multidisciplinary rehabilitation protocols.