Novel Cellular Signalling Axes in Neurodegenerative Diseases: From NLRP3 Inflammasome to Wnt/β-Catenin and Hippo-YAP Pathways.
Novel Cellular Signalling Axes in Neurodegenerative Diseases: From NLRP3 Inflammasome to Wnt/β-Catenin and Hippo-YAP Pathways.
Where did the research take place?
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Mathura, IN · Author affiliation
Department of Pharmacology, Institute of Pharmaceutical Research, GLA University, Mathura, Uttar Pradesh, India.Location evidence
Comilla, BD · Author affiliation
Department of Zoology, Comilla Victoria Government College, National University of Bangladesh, Gazipur, Bangladesh.Location evidence
Gazipur, BD · Author affiliation
Department of Zoology, Comilla Victoria Government College, National University of Bangladesh, Gazipur, Bangladesh.Location evidence
Dehradun, IN · Author affiliation
Department of Microbiology, School of Applied and Life Sciences, Uttaranchal University, Dehradun, Uttarakhand, India.Location evidence
Dhaka, BD · Author affiliation
Department of Mathematics and Natural Sciences, BRAC University, Dhaka, Bangladesh.Location evidence
Chattogram, BD · Author affiliation
Doctor of Veterinary Medicine, Chattogram Veterinary and Animal Sciences University, Chittagong, Bangladesh.Location evidence
Pune, IN · Author affiliation
Department of Biochemistry, Symbiosis Medical College for Women, Symbiosis International (Deemed University), Pune, India.Location evidence
Kanpur, IN · Author affiliation
PSIT-Pranveer Singh Institute of Technology, Pharmacy, NH-19 Bhauti Road Kanpur, Uttar Pradesh, India.Location evidence
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Original abstract
Neurodegenerative diseases (NDs), including Huntington's disease (HD), amyotrophic lateral sclerosis (ALS), Alzheimer's disease (AD), and Parkinson's disease (PD), are characterised by impaired cellular homeostasis and progressive neuronal loss. Emerging evidence highlights the critical role of cellular signalling pathways in the progression and pathogenesis of these disorders. With a focus on the NLRP3 inflammasome, Wnt/β-catenin, and Hippo-YAP cascades, this review focuses on new signalling pathways linked to neurodegenerative disorders. Among them, the NLRP3 inflammasome is a crucial mediator of neuroinflammation, causing neuronal damage and persistent immune activation. In contrast, these pathways regulate neurogenesis, synaptic plasticity, and cell survival, offering potential neuroprotective functions. Dysregulation of these pathways disrupts cellular integrity, exacerbates disease progression, and represents a convergence point for therapeutic intervention. In NDs, knowing how these pathways interact offers fresh perspectives on disease processes and finds new targets for the creation of disease-modifying treatments.