Deep brain stimulation in VPS13C-associated Parkinson's disease: a longitudinal case study.
Deep brain stimulation in VPS13C-associated Parkinson's disease: a longitudinal case study.
Where did the research take place?
The study site has not been established. Author addresses may differ from where the research occurred.
Osaka, JP · Author affiliation
Department of Neurology, Osaka General Medical Center, 3-1-56 Bandai-higashi, Sumiyoshi-ku, Osaka city 558-8558, Osaka, Japan.Location evidence
Suita, JP · Author affiliation
Department of Neurosurgery, The University of Osaka, 2-2 Yamadaoka, Suita 565-0871, Osaka, Japan.Location evidence
Tokyo, JP · Author affiliation
Research Institute for Diseases of Old Age, Graduate School of Medicine, Juntendo University, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan.Location evidence
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Original abstract
•VPS13C parkinsonism showed initial STN-DBS benefit then rapid decline.•Motor, cognitive, and psychiatric deterioration occurred after DBS.•Cardiac MIBG converted from normal uptake to denervation over 7 years.•Findings support genetic testing before DBS in early-onset PD.•Surgicogenomics may guide DBS candidate selection in genetic PD.