[A "prion mechanism" involved in the progression of Parkinson's disease: towards innovative therapeutic approaches?].
[A "prion mechanism" involved in the progression of Parkinson's disease: towards innovative therapeutic approaches?].
Where did the research take place?
The study site has not been established. Author addresses may differ from where the research occurred.
Lyon, FR · Author affiliation
Agence nationale de sécurité sanitaire (ANSES), Université de Lyon, Unité Maladies neuro-dégénératives et du neurodéveloppement (MN2D), Lyon, France.Location evidence
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Original abstract
Knowledge demonstrating the involvement of protein misfolding propagation mechanisms in the progression of Parkinson's disease opens up new therapeutic prospects. This article illustrates this possibility through two recent major publications. The first study focuses on a new receptor (FAM171A2) for abnormally folded α-synuclein protein, which could be blocked to limit the propagation of the pathological protein from cell to cell. The second study highlights that the unstructured ends of this protein have variable positions that may influence its pathogenicity and ability to spread. Modifying this positioning through the action of a substance, such as an antibody, could be an approach to slowing the progression of the disease.