Soft Neural Interfaces for Circuit-Level Analysis of Magnetogenetic Deep Brain Stimulation in Parkinson's Disease Models.
Soft Neural Interfaces for Circuit-Level Analysis of Magnetogenetic Deep Brain Stimulation in Parkinson's Disease Models.
Where did the research take place?
The study site has not been established. Author addresses may differ from where the research occurred.
Seoul, KR · Author affiliation
Department of Materials Science & Engineering, Yonsei University, Seoul, Republic of Korea.Location evidence
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Original abstract
Magnetogenetic deep brain stimulation (MG-DBS) represents a wireless neuromodulation that has demonstrated long-lasting behavioral benefits in Parkinson's disease models. However, the circuit-level mechanisms underlying these therapeutic effects have remained uncharacterized due to limitations of conventional neural interfaces. We present a bio-integrable soft neural interface featuring ultrasoft liquid-metal probes with bioresorbable stiffeners and customizable interconnects directly printed onto cranial surfaces to match individual skull anatomy and nanoparticle injection sites. This platform enables stable multi-regional recordings from deep brain structures without chronic tissue damage. We systematically investigate MG-DBS therapeutic mechanisms in a Parkinson's disease mouse model. Circuit-level analysis reveals that MG-DBS modulates pathological beta-band oscillations and inter-regional synchrony across the cortico-basal ganglia-thalamic circuit. Direct comparison with conventional electrical DBS demonstrates that MG-DBS effects persisted approximately fifteen-fold longer after stimulation cessation. Our electrophysiological recordings elucidate the mechanistic basis for this sustained therapeutic effect, providing unprecedented insights into magnetogenetic neuromodulation dynamics.