Unexpected Cortical Uptake on [ 18 F]FP-CIT PET/CT Revealing Delayed Brain Metastases From Renal Cell Carcinoma.
Unexpected Cortical Uptake on [ 18 F]FP-CIT PET/CT Revealing Delayed Brain Metastases From Renal Cell Carcinoma.
Where did the research take place?
The study site has not been established. Author addresses may differ from where the research occurred.
Daegu, KR · Author affiliation
Department of Nuclear Medicine, Daegu Catholic University School of Medicine, Daegu, Republic of Korea.Location evidence
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Original abstract
A 77-year-old man with a remote history of renal cell carcinoma (RCC) presented with gait disturbance and underwent delayed [ 18 F]FP-CIT PET/CT to evaluate Parkinsonism. The scan showed focal uptake in the temporoparietal and insular cortices with a focal striatal photopenic defect. Brain MRI confirmed enhancing metastases corresponding to the cortical foci and attributed the striatal abnormality to chronic infarction. Hypervascular metastases such as RCC may exhibit cortical [ 18 F]FP-CIT uptake, possibly from increased perfusion and/or altered blood-brain barrier permeability, reflecting nonspecific tracer retention. Therefore, cortical uptake warrants cautious interpretation and appropriate correlation with clinical history and anatomic imaging for differential diagnosis.