Progress in modelling ATP13A2-linked neurodegeneration.
Progress in modelling ATP13A2-linked neurodegeneration.
Where did the research take place?
The study site has not been established. Author addresses may differ from where the research occurred.
IT · Author affiliation · country only
Department of Biology, University of Padova, Padova, Italy.Location evidence
Bordeaux, FR · Author affiliation
Univ. Bordeaux, CNRS, IMN, UMR 5293, F-33000, Bordeaux, France.Location evidence
Venice, IT · Author affiliation
IRCCS San Camillo Hospital, Venice, Italy.Location evidence
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Original abstract
ATP13A2 is a lysosomal P5-ATPase highly expressed in the central nervous system, regulating polyamine, metal cation, and calcium homeostasis. Loss-of-function mutations cause an autosomal recessive juvenile form of Parkinson's disease called Kufor-Rakeb syndrome and other neurodegenerative disorders. Since the first clinical discovery of the Kufor-Rakeb syndrome, numerous ATP13A2-related models have emerged, leading to significant advances in understanding the physiology and pathophysiology of this protein. This review summarizes ATP13A2 structure, function, pathology, and insights gained from cellular and animal models, highlighting their value for elucidating disease mechanisms and therapeutic development across species and experimental systems, relevant to neurodegeneration research broadly.