The COMPEX-trial: computer-based cognitive rehabilitation to improve executive function versus unspecific training in patients after stroke, cardiac arrest or in Parkinson's disease: study protocol for a randomized controlled trial.
The COMPEX-trial: computer-based cognitive rehabilitation to improve executive function versus unspecific training in patients after stroke, cardiac arrest or in Parkinson's disease: study protocol for a randomized controlled trial.
Where did the research take place?
The study site has not been established. Author addresses may differ from where the research occurred.
Copenhagen, DK · Author affiliation
Department of Neurology, Bispebjerg Hospital Bispebjerg Bakke 23, Copenhagen, NV, 2400, Denmark. katrine.svaerke@regionh.dk.Location evidence
Basel, CH · Author affiliation
University Hospital Basel, Basel, Switzerland.Location evidence
Aalborg, DK · Author affiliation
Aalborg University Hospital, Aalborg, Denmark.Location evidence
Glasgow, GB · Author affiliation
University of Glasgow, Glasgow, Scotland.Location evidence
Gothenburg, SE · Author affiliation
University of Gothenburg, Gothenburg, Sweden.Location evidence
A plain-language reading has not been prepared for this paper yet.
Original abstract
RationaleImpairment of the executive functions can be reduced by training, but most traditional approaches require specialized expertise. Therefore, cognitive rehabilitation is only offered to a minority of patients with a need. Computer-based Cognitive Rehabilitation (CBCR) is a low-cost intervention with rehabilitation potential. Outside of hospital rehabilitation institutions, the work is based on dysfunctions and not diagnoses, why patients after stroke, cardiac arrest, or in Parkinson's disease were included based on their dysfunctions with the aim of potential broad implementation.Aim and hypothesisThis trial investigates whether specific CBCR focusing on executive functions is superior to general computer-based cognitive activities in improving working memory.Sample size estimatesBased on a statistical power calculation, 308 participants will be enrolled. A total of 291 patients are currently included in the trial.Methods and designThe trial is a multi-center, investigator-initiated, superiority randomized controlled trial with single blinding. Participants (≥ 18 years) with impaired working memory following stroke, cardiac arrest, or Parkinson's disease will be randomized (1:1) to either specific CBCR using Scientific BrainTraining Pro (Happy Neuron) or an active control group performing unspecific cognitive activities. The intervention lasts eight weeks (60 min/day, 5 days/week). Six centers are involved in the trial and completion of inclusion is expected in November 2025.Study outcome(s)The primary outcome is working memory, assessed by CABPad. Secondary outcomes include instrumental activities of daily living, mood, anxiety, and quality of life measures.DiscussionThis trial will provide evidence on the efficacy of CBCR in enhancing executive functions, potentially guiding future clinical implementation.Trial registrationThe trial is registered at Clinicaltrials.gov with identifier: NCT04229056. Registered on January 6, 2020.