Conformal bumped electrode web for chronic ECoG recordings in swine.
Conformal bumped electrode web for chronic ECoG recordings in swine.
Where did the research take place?
The study site has not been established. Author addresses may differ from where the research occurred.
Hangzhou, CN · Author affiliation
MOE Engineering Research Center of Smart Microsensors and Microsystems, School of Electronics and Information, Hangzhou Dianzi University, Hangzhou, China.Location evidence
Dianzi, CN · Author affiliation
MOE Engineering Research Center of Smart Microsensors and Microsystems, School of Electronics and Information, Hangzhou Dianzi University, Hangzhou, China.Location evidence
Wenzhou, CN · Author affiliation
Wenzhou Institute of Hangzhou Dianzi University, Wenzhou, China.Location evidence
CN · Author affiliation · country only
National Key Laboratory of Unmanned Aerial Vehicle Technology, Unmanned System Research Institute, School of Artificial Intelligence, Northwestern Polytechnical University, Xi'an, China.Location evidence
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Original abstract
The acquisition of high-quality electrocorticogram (ECoG) signal is of great significance for the diagnosis and treatment of neurological diseases such as high amputation, visual injury, epilepsy and Parkinson's disease. Currently, flexible ECoG electrodes have received attention due to their low mechanical mismatch and minimally invasive characteristics. However, the traditional ECoG electrodes are non-stretchable planar structures that cannot be conformal with the cerebral cortex, which is in constant motion and has sulci and gyri structure. In this work, a flexible stretchable ECoG electrode with bumped electrodes was developed to alleviate these problems. Firstly, the mechanical simulation results show that this stretchable electrode structure can effectively reduce the stress mismatch between electrode and tissue interface. Secondly, the results of cyclic voltammetry scanning and mechanical tensile experiments show that the stretchable ECoG electrode structure can be conformally attached to the surface of the cerebral cortex and maintain good electrochemical stability during continuous stretching. Third, the bumped electrode has a larger adhesive force than the planar electrode and can significantly reduce the background noise by conformal attachment and electrochemical modification of PEDOT:PSS. Most importantly, in vivo animal experiments showed that the stretchable ECoG electrode can continuously record high-quality ECoG signals on the surface of the cerebral cortex of swine over an area of 22 × 22 mm2 for more than 5 weeks.