Hydrogen sulfide protects dopaminergic neurons via NLRP3 inflammasome inhibition in an MPTP mouse model of Parkinson's disease.
Hydrogen sulfide protects dopaminergic neurons via NLRP3 inflammasome inhibition in an MPTP mouse model of Parkinson's disease.
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Chengdu, CN · Author affiliation
Department of Neurology, Chengdu Seventh People's Hospital (Affiliated Cancer Hospital of Chengdu Medical College), Chengdu 610213, Sichuan Province, PR China; Nanfang Hospital, Southern Medical University, Guangzhou 510515, Guangdong Province, PR China.Location evidence
Guangzhou, CN · Author affiliation
Department of Neurology, Chengdu Seventh People's Hospital (Affiliated Cancer Hospital of Chengdu Medical College), Chengdu 610213, Sichuan Province, PR China; Nanfang Hospital, Southern Medical University, Guangzhou 510515, Guangdong Province, PR China.Location evidence
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Original abstract
BACKGROUND: Hydrogen sulfide (H2S) has emerged as a potential neuroprotective agent in neurodegenerative diseases, including Parkinson's disease (PD). However, its role in regulating neuroinflammation through the NLRP3 inflammasome remains unclear. METHODS: We established a PD mouse model using MPTP (30 mg/kg, i.p. for 5 days) and administered NaHS (an H2S donor, 5.6 mg/kg, i.p.) daily during the same period. Behavioral tests, immunohistochemistry, and Western blotting were used to assess motor function, dopaminergic neuron survival, NLRP3 inflammasome activation, and inflammatory cytokine levels. RESULTS: NaHS significantly improved motor deficits and preserved tyrosine hydroxylase (TH)-positive neurons in the substantia nigra. It markedly suppressed the expression of NLRP3, ASC, cleaved caspase-1, and IL-1β, indicating inhibition of inflammasome activation. CONCLUSION: Exogenous H2S protects dopaminergic neurons in MPTP-induced PD mice, likely by suppressing NLRP3 inflammasome activation, suggesting its therapeutic potential for PD.