Advances in design and application of molecularly imprinted polymers for selective brain protein recognition in neurology.
Advances in design and application of molecularly imprinted polymers for selective brain protein recognition in neurology.
Where did the research take place?
The study site has not been established. Author addresses may differ from where the research occurred.
Noida, IN · Author affiliation
Molecular Science and Engineering Laboratory, Amity Institute of Click Chemistry Research and Studies, Amity University, Uttar Pradesh, Sector- 125, Noida, UP 201313, India.Location evidence
Rāman, IN · Author affiliation
Department of Chemistry, C. V. Raman Global University, Bhubaneswar, Odisha 752054, India.Location evidence
Bhubaneswar, IN · Author affiliation
Department of Chemistry, C. V. Raman Global University, Bhubaneswar, Odisha 752054, India.Location evidence
IN · Author affiliation · country only
Department of Pharmacology, Amity Institute of Pharmacy, Amity University Haryana, Amity Education Valley, Gurgaon, Haryana 122413, India.Location evidence
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Original abstract
Neurological diseases affect billions of people worldwide, including an array of infections, strokes, cancers, and neurodegenerative disorders like Alzheimer's and Parkinson's, which have seen rising mortality rates in recent decades. The blood-brain barrier (BBB) is a critical protective layer composed of tightly sealed endothelial cells that restrict the entry of most molecules into the brain. Typically, only small, lipophilic molecules can cross the BBB, while larger or hydrophilic drugs face significant delivery challenges. Molecularly imprinted polymers (MIPs) are synthetic materials designed to recognize specific molecules, creating 'molecular memory' for selective binding and release. MIPs offer benefits such as high stability, biocompatibility, sustained drug release, and cost-effectiveness, making them promising candidates for drug delivery and biosensing applications. This review explores the potential of MIPs for targeting receptors on the BBB to improve selective drug delivery to the brain, highlighting design strategies and receptor targets critical for internalization.