Real-world multicenter assessment of sustained clinical outcomes after digital deep brain stimulation.
Real-world multicenter assessment of sustained clinical outcomes after digital deep brain stimulation.
Where did the research take place?
The study site has not been established. Author addresses may differ from where the research occurred.
Tübingen, DE · Author affiliation
Institute for Neuromodulation and Neurotechnology, Faculty of Medicine, University Hospital Tübingen (UKT), University Tübingen, Tübingen, Germany. alireza.gharabaghi@uni-tuebingen.de.Location evidence
Stuttgart, DE · Author affiliation
Center for Bionic Intelligence Tübingen Stuttgart (BITS), Tübingen, Germany. alireza.gharabaghi@uni-tuebingen.de.Location evidence
Homburg, DE · Author affiliation
Department of Neurology, University Hospital Homburg, Homburg, Germany.Location evidence
Madrid, ES · Author affiliation
Neurosurgery Department, La Princesa University Hospital, Madrid, Spain.Location evidence
Düsseldorf, DE · Author affiliation
Department of Neurology, and Institute of Clinical Neuroscience and Medical Psychology, Medical Faculty and University Hospital Düsseldorf, Heinrich-Heine University Düsseldorf, Düsseldorf, Germany.Location evidence
Sevilla, ES · Author affiliation
Unidad de Trastornos del Movimiento, Servicio de Neurología y Neurofisiología Clínica. Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Sevilla, Spain.Location evidence
Universidad, ES · Author affiliation
Unidad de Trastornos del Movimiento, Servicio de Neurología y Neurofisiología Clínica. Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Sevilla, Spain.Location evidence
Centro, ES · Author affiliation
Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain.Location evidence
Glasgow, GB · Author affiliation
Department of Neurology, Institute of Neurological Sciences, Queen Elizabeth University Hospital, Glasgow, UK.Location evidence
Chicago, US · Author affiliation
Department of Neurological Sciences, Rush University, Chicago, IL, USA.Location evidence
Davis, US · Author affiliation
Department of Neurology, University of California, Davis, Sacramento, CA, USA.Location evidence
Sacramento, US · Author affiliation
Department of Neurology, University of California, Davis, Sacramento, CA, USA.Location evidence
Badalona, ES · Author affiliation
Departamento de Neurociencias, Unidad de Enfermedades Neurodegenerativas, Servicio de Neurologia, Hospital Universitari Germans Trias I Pujol, Badalona, Spain.Location evidence
LB · Author affiliation · country only
Department of Neurology, Dartmouth-Hitchcock Medical Center, Lebanon, NH, USA.Location evidence
US · Author affiliation · country only
Department of Neurology, Dartmouth-Hitchcock Medical Center, Lebanon, NH, USA.Location evidence
Boston, US · Author affiliation
Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.Location evidence
IL · Author affiliation · country only
Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.Location evidence
Indianapolis, US · Author affiliation
Department of Neurology, Indiana University School of Medicine, Indianapolis, IN, USA.Location evidence
Philadelphia, US · Author affiliation
Department of Neurological Surgery, Thomas Jefferson University, Philadelphia, PA, USA.Location evidence
Tucson, US · Author affiliation
Department of Neurology, University of Arizona, Tucson, AZ, USA.Location evidence
Miami, US · Author affiliation
Department of Neurology, University of Miami, Miami, FL, USA.Location evidence
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Following implanted brain stimulation over the long term
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Remote Optimization, Adjustment and Measurement for Deep Brain Stimulation
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Original abstract
Remote, internet-based deep brain stimulation programming for Parkinson's disease accelerates clinical benefits postoperatively by improving access to therapy adjustments compared to in-clinic optimization. After completion of the initial digital programming phase, we show that clinical outcomes, quality of life, and safety remain sustained over at least twelve months under routine care conditions. Embedding a randomized trial within a larger cohort study enables long-term, real-world evaluation, offering a scalable and pragmatic model for assessing complex digital interventions in routine clinical care. (NCT05269862 registered on 2022-03-08 and NCT04071847 registered on 2019-08-28).