Propensity-matched multicenter comparison of Parkinson's disease outcomes with and without deep brain stimulation.
Propensity-matched multicenter comparison of Parkinson's disease outcomes with and without deep brain stimulation.
Where did the research take place?
The study site has not been established. Author addresses may differ from where the research occurred.
Tübingen, DE · Author affiliation
Institute for Neuromodulation and Neurotechnology, University Hospital and University of Tübingen, 72076, Tübingen, Germany. alireza.gharabaghi@uni-tuebingen.de.Location evidence
Stuttgart, DE · Author affiliation
Center for Bionic Intelligence Tübingen Stuttgart (BITS), 72076, Tübingen, Germany. alireza.gharabaghi@uni-tuebingen.de.Location evidence
Toronto, CA · Author affiliation
Max Planck-University of Toronto Centre for Neural Science & Technology (MPUTC), Toronto (Canada), Tübingen, Germany. alireza.gharabaghi@uni-tuebingen.de.Location evidence
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Original abstract
Subthalamic deep brain stimulation is established for Parkinson's disease, reducing funding for randomized trials and necessitating complementary approaches to assess outcomes in broader clinical contexts. Using publicly available multicenter data, we compared propensity-matched patients with and without stimulation. The intervention was associated with improved mid-term patient-reported motor and non-motor experiences of daily living, while ongoing follow-up will clarify long-term effects. This demonstrates feasibility of matched comparisons in open observational cohorts.