[Hoehn & Yahr scale and MDS-UPDRS Part 3 progression in Parkinson's disease patients: retrospective natural history study using a disease registry].
[Hoehn & Yahr scale and MDS-UPDRS Part 3 progression in Parkinson's disease patients: retrospective natural history study using a disease registry].
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Original abstract
The objective was to elucidate the relationship between the Hoehn and Yahr scale (HY) and the MDS-UPDRS Part 3 at the OFF state in patients with Parkinson's disease (PD). We conducted a retrospective natural history study using the Parkinson's Progression Markers Initiative database, a large international observational study. The results showed a parallel increase in MDS-UPDRS Part 3 with HY scale. The MDS-UPDRS Part 3 was estimated to increase by 1.90 per year. The median time to HY deterioration were 11, 140, 84, and 47 months for HY 1 to 4, respectively. This study has quantified the motor symptom progression of PD and provided useful information for future clinical trial planning and health economic evaluation of PD treatment.