Ocular motor dysfunction in patients with multiple system atrophy and Parkinson's disease.
Ocular motor dysfunction in patients with multiple system atrophy and Parkinson's disease.
Where did the research take place?
The study site has not been established. Author addresses may differ from where the research occurred.
Beijing, CN · Author affiliation
Department of Neurology, Peking University First Hospital, Beijing 100034, China.Location evidence
CN · Author affiliation · country only
The Third Affiliated Hospital of Jinzhou Medical University, Jinzhou 121000, China.Location evidence
Seoul, KR · Author affiliation
Dizziness Center, Seoul National University Bundang Hospital, Seongnam, South Korea; Department of Neurology, Seoul National University College of Medicine, Seoul, South Korea.Location evidence
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Original abstract
ObjectiveDifferentiating multiple system atrophy (MSA) from Parkinson's disease (PD) remains challenging. This study aimed to investigate the utility of specific ocular motor features in distinguishing MSA from PD, as these dysfunctions may offer valuable diagnostic clues.MethodsWe used video-oculography to assess spontaneous nystagmus, saccadic intrusions or oscillations, gaze, saccades, head shaking, positional nystagmus, and vestibulo-ocular reflex (VOR) cancellation in 23 MSA patients and 49 PD patients.ResultsSpontaneous downbeat nystagmus, saccadic intrusions/oscillations, and perverted head shaking nystagmus (pHSN) didn't differ between groups. Horizontal gaze-evoked nystagmus (GEN) occurred in MSA patients but not in PD (P = 0.009). MSA showed significantly more prolonged saccade latency (both horizontal and vertical) and vertical saccadic hypermetria than PD (all P < 0.05). Central positional nystagmus (CPN) was more common in MSA (P = 0.046). Impaired VOR cancellation was significantly higher in MSA than in PD (95.7 % vs. 32.7 %, P < 0.001).ConclusionMSA exhibits significantly more pronounced VOR cancellation deficits, horizontal GEN, CPN, saccadic hypermetria, and prolonged saccade latency than PD. These findings suggest a link to the more widespread neurodegeneration characteristic of MSA.SignificanceImpaired VOR cancellation, horizontal GEN, saccadic hypermetria, and CPN offer potential for distinguishing MSA from PD.