Plasma Neurofilament Light Chain and TNF-α Correlate with Motor Features in Isolated REM Sleep Behavior Disorder.
Plasma Neurofilament Light Chain and TNF-α Correlate with Motor Features in Isolated REM Sleep Behavior Disorder.
Where did the research take place?
The study site has not been established. Author addresses may differ from where the research occurred.
London, GB · Author affiliation
Centre for Preventive Neurology, Charterhouse Square, Queen Mary University of London, London, UK.Location evidence
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Original abstract
BACKGROUND: Isolated RBD (iRBD) is a prominent early marker of Parkinson's disease and related disorders. OBJECTIVES: Evaluate biomarkers of inflammation and axonal damage people with iRBD for disease progression. METHODS: Plasma samples from 27 video-polysomnography confirmed iRBD patients and 25 controls were analyzed for inflammatory biomarkers (CRP, IL-6, TNF-α, IFN-γ, IL-1β) and NfL using the Meso Scale Discovery platform. RESULTS: People with iRBD had elevated plasma TNF-α and IL-6 (p = 0.013 and p = 0.051). In the iRBD group, plasma NfL was associated with objective motor tests: Timed Up and Go (R2 = 0.292, p = 0.027) and 10-m walk (R2 = 0.355, p = 0.034) and plasma TNF-α was associated with the Timed Up and Go test (R2 = 0.277, p = 0.025). CONCLUSIONS: We report evidence of peripheral inflammation in early synuclein-related disease processes, and association of plasma NfL and TNF-α with motor dysfunction in iRBD patients, suggesting possible association with increased risk of phenoconversion.