Is Parkinson Disease Better Defined Solely by Biology or as a Clinical–Biological Entity? Lessons to be Learned from Alzheimer's Disease on Biological Definition and Staging
Is Parkinson Disease Better Defined Solely by Biology or as a Clinical–Biological Entity? Lessons to be Learned from Alzheimer's Disease on Biological Definition and Staging
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Original abstract
The development of Alzheimer's disease (AD) classification and staging systems between 2000 and 2010 marked significant progress in integrating the neurodegenerative process and clinical syndrome. This progress was made possible by improved techniques for measuring amyloid and tau deposition in vivo. Two schemas emerged: the National Institute on Aging and Alzheimer Association (NIA-AA) framework and the International Working Group (IWG) approach. The NIA-AA framework ultimately gained international recognition through its 2011 and 2018 publications, the latter suggesting a biological definition for AD. © 2025 International Parkinson and Movement Disorder Society info:eu-repo/semantics/publishedVersion