[REM-Sleep-Behavior Disorder - More Than a Simple Parasomnia].
[REM-Sleep-Behavior Disorder - More Than a Simple Parasomnia].
Where did the research take place?
The study site has not been established. Author addresses may differ from where the research occurred.
Bern, CH · Author affiliation
Universitätsklinik für Pneumologie, Allergologie und Klinische Immunologie, Inselspital, Universitätsspital Bern, Universität Bern, Schweiz.Location evidence
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Original abstract
Rapid-Eye-Movement (REM) sleep is an essential part of sleep dominating the second half of the night. A disturbance of the phy-siological muscle hypotonia of REM sleep can lead to dream enactment: REM sleep behavior disorder (RBD). In the absence of a disease of the central nervous system or provoking factors such as sleep apnea, alcohol consumption or antidepressants, isolated RBD (iRBD) may be present. IRBD is an early stage of alpha-synucleinopathies such as Parkinson's disease, dementia with Lewy bodies and multisystem atrophy. Medical history and polysomnography are the most important diagnostic tools. Clonazepam and melatonin are symptomatic treatments used to prevent injury. New technologies enable long-term monitoring of disease progression in iRBD and thus guide the targeted use of future disease-modifying therapies.