A network perspective on cognition in individuals with Parkinson's disease.
A network perspective on cognition in individuals with Parkinson's disease.
Where did the research take place?
The study site has not been established. Author addresses may differ from where the research occurred.
DE · Author affiliation · country only
Medical Psychology, Neuropsychology and Gender Studies Center for Neuropsychological Diagnostics and Intervention (CeNDI) University Hospital Cologne and Faculty of Medicine University of Cologne Cologne Germany.Location evidence
Munich, DE · Author affiliation
Ethikkommission Ludwig-Maximilians-Universität München Munich Germany.Location evidence
Kiel, DE · Author affiliation
Department of Neurology University Medical Center Schleswig-Holstein, Christian Albrechts-University (CAU) Campus Kiel Kiel Germany.Location evidence
Recklinghausen, DE · Author affiliation
Department of Neurology Klinikum Vest Recklinghausen Germany.Location evidence
Bochum, DE · Author affiliation
Faculty of Medicine Ruhr-University Bochum Germany.Location evidence
Tübingen, DE · Author affiliation
Department of Neurodegenerative Diseases Hertie Institute for Clinical Brain Research and German Center for Neurodegenerative Diseases (DZNE) University Tübingen and German Center for Neurodegenerative Diseases Tübingen Germany.Location evidence
Stuttgart, DE · Author affiliation
Department of Psychology IB-Hochschule Stuttgart Germany.Location evidence
Kassel, DE · Author affiliation
Department of Neurology Paracelsus-Elena Klinik Kassel Germany.Location evidence
Göttingen, DE · Author affiliation
Department of Neurosurgery University Medical Center Göttingen Germany.Location evidence
Aachen, DE · Author affiliation
Department of Neurology RWTH Aachen University Hospital Aachen Germany.Location evidence
Jülich, DE · Author affiliation
JARA Institute Molecular Neuroscience and Neuroimaging (INM-11) Research Center Jülich Jülich Germany.Location evidence
Bremen, DE · Author affiliation
Department Clinical Epidemiology Leibniz Institute for Prevention Research and Epidemiology-BIPS Bremen Germany.Location evidence
Bonn, DE · Author affiliation
German Center for Neurodegenerative Diseases (DZNE) Bonn Germany.Location evidence
Rostock, DE · Author affiliation
Department of Neurology University of Rostock and German Center for Neurodegenerative Diseases (DZNE) Rostock/Greifswald Rostock Germany.Location evidence
Oldenburg, DE · Author affiliation
Department of Neurology School of Medicine and Health Sciences and Research Center Neurosensory Science University of Oldenburg Oldenburg Germany.Location evidence
Essen, DE · Author affiliation
Department of Geriatric Medicine University Duisburg-Essen Essen Germany.Location evidence
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Original abstract
IntroductionIn neuropsychological diagnostics, the assignment of cognitive tests to domains is usually not empirically based. Hence, we aimed to assess the dimensionality structure of cognition in individuals with Parkinson's disease (PD) and conceptually replicate the findings in cognitively healthy individuals (CHIs).MethodsWe performed Exploratory Graph Analysis (EGA) for dimensionality analysis of cognitive test scores in N = 698 individuals with PD from the DEMPARK/LANDSCAPE study. Redundancy was reduced based on Unique Variable Analysis (UVA) before re-performing EGA. CHI data (N = 60,398) served as a conceptual replication base.ResultsEGA identified five dimensions. After removing redundancy identified by UVA, EGA identified a unidimensional structure of cognitive test scores. The findings were conceptually replicated in CHIs.DiscussionThe findings imply the need to re-evaluate the composition of cognitive test batteries to reduce redundancy and improve the validity of cognitive diagnostics. Cognition may be better described as a network of interrelated cognitive functions rather than a factorial structure of latent cognitive domains.HighlightsCognitive test scores of the same paradigm were strongly associated with each other.This finding indicates redundancy in the cognitive test battery.After removing redundancy, scores were best represented by unidimensional structures.The findings in Parkinson's disease were conceptually replicated in healthy controls.The results suggest that cognition should be viewed as a complex "network" of interrelated functions.