[Research progress on Pb-induced neurotoxicity through glial cells].
[Research progress on Pb-induced neurotoxicity through glial cells].
Where did the research take place?
The study site has not been established. Author addresses may differ from where the research occurred.
CN · Author affiliation · country only
Department of Occupational Medicine and Environmental Toxicology, School of Public Health, Nantong University, Nantong 226000, China Nantong Key Laboratory of Environmental Toxicology, Nantong 226000, China.Location evidence
A plain-language reading has not been prepared for this paper yet.
Original abstract
Lead is one of the most important occupational hazards in China, and occupational exposure is the leading cause of lead poisoning. Lead can be absorbed by the body through air, food, drinking water and skin, and accumulate in multiple organs in the body, posing health risks to humans, especially to lead workers. Many previous studies have shown that lead can affect the function of glial cells such as microglia, astrocytes and oligodendrocytes, resulting in irreversible neurological damage. This article provides an overview of the neurotoxic mechanism induced by lead through glial cells, elucidates that lead can induce neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis, and reviews the relationship between lead and glial cells, in order to provide reference for further research on the neurotoxic mechanism of lead on glial cells.