[Perspective of α-synuclein and Familial Parkinson's Disease].
[Perspective of α-synuclein and Familial Parkinson's Disease].
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Original abstract
To date, there have been several reports about the genes associated with familial Parkinson's disease. These genes are classified following the PARK nomenclature. The prevalence of these genes varies between countries. Moreover, each gene is associated with different symptoms during disease progression. In this review, we will summarize the clinical findings and molecular functions, with a focus on alpha-synuclein, along with recent discoveries and will try to associate them with sporadic Parkinson's disease.