Parkinsonism
Parkinsonism
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Original abstract
Parkinsonism is a broad term comprising a clinical syndrome and presenting with various neurodegenerative diseases, which manifest with motor symptoms such as rigidity, tremors, bradykinesia, and unstable posture, leading to profound gait impairment. Parkinson disease accounts for approximately 80% of cases, while the remainder comprises a collection of other neurodegenerative diseases with similar motor symptoms. James Parkinson was the first author to describe a case series of 6 patients in an essay titled "An Essay on the Shaking Palsy," published in 1817. Although parkinsonism is a characteristic feature of Parkinson disease, similar symptoms can also arise from other neurodegenerative disorders, specific brain lesions, head trauma, medications, metabolic conditions, and exposure to toxins.