Animal models for Parkinson's disease.
Animal models for Parkinson's disease.
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Original abstract
Parkinson's disease (PD) is one of the most common degenerative disorders of the CNS, characterized by motor syndrome, for example, tremor, rigidity, bradykinesia, and postural instability. Parkinson's disease was first described in 1817, but the pathogenesis still remains unclear. An animal model is very important, in order to explore the pathogenesis, to search for translatable biomarkers, and verify the efficacy of experimental therapeutic interven- tions. However, there is no perfect animal model of PD. Animal model for PD need 1) clinical symptoms of parkinsonism, 2) selective catecholaminergic neuronal loss, and 3) Lewy bodies and Lewy neurites. We deal here with representative animal models for PD, including drug-induced models (MPTP, Rotenone, 6-OHDA) and genetic models (α-synuclein, PARKIN: PINK1).