Genes for Parkinson's disease.
Genes for Parkinson's disease.
Where did the research take place?
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Original abstract
Parkinson's disease (PD) is caused by multiple genetic and environmental factors. ~14 disease causing genes have been identified for familial form of Parkinson's disease studies of which indicate a cell death pathway in dopaminergic neurons induced by defective protein degradation as a key molecular mechanism underlying the pathogenesis of PD. Yet the majority of PD cases are sporadic, which is a multifactorial genetic disorder. We performed genome-wide association study (GWAS) and identified four PD- susceptibility loci. Now, large-scale meta-analysis of GWAS identifies total of -30 genes. Rare variants, less common yet associated with high risks for the disease onset, are also important, and Gaucher disease mutations are proven to be a definite rare variant risk factor for PD.