Conceptual definition in the metamorphosing Parkinson's disease.
Conceptual definition in the metamorphosing Parkinson's disease.
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Original abstract
Two hundred years ago, James Parkinson wrote 'An Essay on the Shaking Palsy'. The discovery of Lewy bodies in the substantia nigra and dopamine deficiency in the nigro- striatal dopaminergic system have confirmed the disease concept of Parkinson's disease. Dopamine replacement therapy dramatically improves the clinical prognosis. However, variable nonmotor symptoms have been noticed by many clinical researches, which can deteriorate the quality of life. Visual hallucination, fall and dementia can prescribe the late stage prognosis. In addition, part of nonmotor symptoms can develop before motor symptoms appear. Nowadays, the prodromal stage of Parkinson's disease may be detected using with the research criteria. The disease concept of Parkinson's disease is still metamorphosing under the storage of the novel evidences.