[Observations on fatigue, depression and quality of life in patients with Parkinson's disease].
[Observations on fatigue, depression and quality of life in patients with Parkinson's disease].
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CN · Author affiliation · country only
Department of Neurology, 2nd Affiliated Hospital of Soochow University, Suzhou 215004, China.Location evidence
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Original abstract
OBJECTIVE: To identify the association between fatigue and depression in Parkinson's disease (PD). METHODS: 56 PD patients were enrolled in this study. The degree of fatigue was measured by Fatigue Severity Scale (FSS). Hamilton Depression Scale (24 items) was used to evaluate the degree of depression. PD Quality of Life Questionnaire (PDQL) were tested to evaluate the quality of life in PD patients. While other clinical information such as Unified Parkinson's Disease Rating Scale (UPDRS) III, Hoehn-Yahr Scale and modified Webster Scale were investigated. RESULTS: The incidence of fatigue in this group is 71.4% (40/56). Score of HAMD and PDQL exhibited a significant correlation to patients' fatigue, coefficient of partial correlation was 0.451 (P < 0.01), -0.346 (P < 0.05). The incidence of fatigue in non-depressive patients was low, 27.3%. While in depressive patients, the incidence of fatigue is relatively high, for mild depression 75%, moderate depression 100%, severe depression 100% respectively. CONCLUSIONS: Fatigue is a prominent symptom of depression in PD patients, sometimes independent of depression also influencing the patients' quality of life.