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[Research advance of the protective role of PACAP in the nervous system diseases].

[Research advance of the protective role of PACAP in the nervous system diseases].

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Xuzhou, CN · Author affiliation

Department of Anesthesia Physiology, Xuzhou Medical College Jiangsu Key Laboratory of Oresthesiology, Xuzhou 221004, China.
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Original abstract

In the central nervous system, pituitary adenylate cyclase-activating polypeptide (PACAP) exerts different actions as neurotransmitter, neuromodulator, neurotrophic and neuroprotective factors via multiple signaling pathways. PACAP plays an important protective role in the nervous system diseases, such as focal cerebral ischemia, traumatic brain injury (TBI), schizophrenia, anxiety disorders Parkinson's disease and Alzheimer's disease. Now, we reviewed the research advances about the protective role of PACAP in the nervous system diseases.

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