[Effect of high-frequency stimulation to subthalamic nucleus on STR neuronal firing rates in Parkinson disease rats].
[Effect of high-frequency stimulation to subthalamic nucleus on STR neuronal firing rates in Parkinson disease rats].
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Original abstract
AIM: To observe the change of STR neuronal firing rates with high frequency stimulation of subthalamic nucleus in PD rats. METHODS: A model of Parkinson's disease was induced by unilateral administration of 6-hydroxydopamine into right substantia nigra in rats. After the high-frequency stimulation to STN, the spontaneous firing rates of STR on normal and PD rats were recorded by using extracellular recordings. RESULTS: Stimulation caused a direct excited effect of STR neurons in normal rats whereas a excited and inhibited effect in PD rats. The inhibited effect was correlated with the stimulation period (r = 0.94). CONCLUSION: Stimulation to STN may inhibit the spontaneous firing rates of STR neurons in PD rats. These results also give some clues that high-frequency stimulation to STN may be a effective therapy to the clinical treatment of Parkinson's disease.