[Dopaminergic Neurotransmission in Parkinson's syndrome (author's transl)].
[Dopaminergic Neurotransmission in Parkinson's syndrome (author's transl)].
A plain-language reading has not been prepared for this paper yet.
Original abstract
More recent electrophysiological and biochemical data dealing with the functioning of the central dopaminergic synapse are reviewed in relationship to Parkinsonian symptomatology. Emphasis is put on the influence of feedback mechanisms involving pre and postsynaptic receptor sites, the dopaminergic-cholinergic imbalance and receptor supersentitivity. Stimulation of the dopamine-sensitive adenylatecyclase proved to be a good indicator of central dopaminergic receptor stimulation. Current therapeutic concepts are discussed in view of their limitations and side-effects.