[Collection of a Chinese pedigree with Parkinson's disease and linkage analysis of nine susceptibility genes].
[Collection of a Chinese pedigree with Parkinson's disease and linkage analysis of nine susceptibility genes].
Where did the research take place?
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Kunming, CN · Author affiliation
Department of Medical Genetics, Institute of Medical Biology, CAMS and PUMC, Kunming 650118, China.Location evidence
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Original abstract
OBJECTIVE: To analyze the susceptibility genes of a Parkinson's Disease (PD) family. METHODS: The blood samples of a four-generation classic idiopathic PD family were collected. Two-point LOD score method was applied to analyze the linkage disequilibrium between the disease locus and microsatellite markers. RESULTS: We studied 13 markers near the 9 genes that had been reported to be associated with PD. No obvious evidence showed that the selected markers had anything correlation with PD locus. CONCLUSION: These 9 genes are not the susceptibility genes of PD in this family.