RESEARCH / DISCOVERY
← Back to the library

[ES cell therapy for Parkinson's disease].

[ES cell therapy for Parkinson's disease].

Read the original publication

A plain-language reading has not been prepared for this paper yet.

Original abstract

Neural transplantation, as a treatment for advanced Parkinson's disease (PD), has been studied for more than a decade due to the potential replacement of degenerated dopaminergic (DA) neurons. Several open-label studies on implantation of fetal nigral neurons revealed improvement in motor functions. However, the benefits were incomplete in double-blind trials. Progressive neural or embryonic stem (ES) cell research has raised hopes of creating novel cell replacement therapies for PD. DA neurons have been efficiently produced from primate ES cells in astrocyte-conditioned medium. Transplantation of neuronal stem cells derived from primate ES cells into a primate model of PD restored striatal DA function, suggesting ES cells are suitable donor cells.

Explore another example or bring your own paper

Pasted text and PDF extraction stay on this computer. The local guide explains terms and surfaces passages; rewriting requires a configured local model. Scanned PDFs need OCR first.

RECORD & PROVENANCE