[A new point mutation on exon 2 of parkin gene in Parkinson's disease].
[A new point mutation on exon 2 of parkin gene in Parkinson's disease].
Where did the research take place?
The study site has not been established. Author addresses may differ from where the research occurred.
Guangzhou, CN · Author affiliation
Department of Neurology, the First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, Guangdong, 510080 P.R.China. yanmingxu@163.netLocation evidence
A plain-language reading has not been prepared for this paper yet.
Original abstract
OBJECTIVE: To detect the relationship between point mutations on exon 2 of parkin gene and sporadic early-onset Parkinson's disease. METHODS: The point mutations on exon 2 of parkin gene were detected using polymerase chain reaction(PCR), agarose electrophoresis, single strand conformation polymorphism(SSCP), DNA sequencing and analysis of restrict enzyme in DNA of 60 Parkinson's disease patients with an onset age under 50 and 120 normal controls. RESULTS: One homozygous mutation (G(237)-->C) on exon 2 was found by sequencing and verified by analysis of restrict enzyme, whereas no mutation was found in normal controls. CONCLUSION: Point mutations on exon 2 of parkin gene are likely to be related to sporadic early-onset Parkinson's disease.