[Effects of yanggan xifeng recipe on changes of neurological behavior of rat of Parkinson's model].
[Effects of yanggan xifeng recipe on changes of neurological behavior of rat of Parkinson's model].
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Original abstract
OBJECTIVE: To investigate the effect of Yanggan Xifeng Recipe (YGXFR) for nourishing Liver to calm down endogenous Wind on neurological behavior of Parkinson's disease (PD) rat model. METHODS: PD rat model was established by destroying the substantia nigra condense area (SNc) and ventral tegmental area (VTA) unilaterally with 6-hydroxy dopamine (6-OHDA). The rats for control were injected in the same site with the same dose of normal saline. The animals were randomly divided into 3 groups (7 in each group), the control group, the model group and the TCM treated group. Staircase test and rotation test induced by apomorphine were performed in all groups and compared. RESULTS: The staircase test demonstrated that, after being treated with YGXFR, the food pellets intake were increased compared to model group (P < 0.05), and their rotation induced by apomorphine was lessened (P < 0.01). CONCLUSION: YGXFR could recover the neurological behavior deficits of PD rat models.